By Michal Linial, Alfonso Grasso, Phillip Lazarovici
This quantity offers with the relationships among pollutants and probably the most basic techniques in any residing phone - the secretory cycle. The reader will locate updated details on secretion, generated by means of specialists during this quick evolving box. within the final decade huge molecular and mobile stories have uncovered the molecular similarity between so much recognized secretory structures. during this publication secretion is mentioned from its easy mode present in yeast as much as its so much subtle model in neurotransmitter unencumber in nerve terminals. A complete view at the mode of motion of poisons which block secretion but in addition these which reason hyper-activation of exocytosis is equipped. This e-book addresses the problem of toxin motion via interpreting the molecular and mobile foundation of exocytosis in numerous organisms and mobile contents.
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Additional info for Secretory Systems and Toxins (Cellular and molecular mechanisms of toxin action)
This has led to the suggestion that, like dynamin, synaptojanin may also have a role in endocytosis and synaptic vesicle recycling. CONCLUDING REMARKS The identification of synaptic vesicle proteins and their associates through molecular approaches has advanced dramatically during the past 5 years. Despite these advances, many more proteins will need to be identified and characterized before a complete picture of the mechanisms controlling neurotransmitter release can be obtained. However, since these mechanisms are likely to be the same as those which control most membrane SYNAPTIC VESICLE PROTEINS 31 movements in virtually all cell types, vast amounts of knowledge will be obtained from, and shared with, other fields of cell biology.
1993) Yeast syntaxins Sso1p and Sso2p belong to a family of related membrane proteins that function in vesicular transport. , 12, 4095–4104. , Greengard, P. M. (1992a) Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: requirement for synaptophysin. Science, 257, 657–661. , Greengard, P. M. (1992b) Antibodies to synaptophysin interfere with transmitter secretion at neuromuscular synapses. Neuron, 9, 759–68. , Greengard, P. M. (1995) Overexpression of synaptophysin enhances neurotransmitter secretion at Xenopus neuromuscular synapses.
Science, 257, 255–259. D. H. (1993a) The syntaxin family of vesicular transport receptors. Cell, 74, 863–873. G. H. (1993b) Casein kinase II phosphorylates the synaptic vesicle protein p65. J. , 13, 1701–1707. H. W. (1995) Functional impact of syntaxin on gating of N-type and Q-type calcium channels. Nature, 378, 623–626. , Niemann, H. and Pohlner, J. (1995) IgA protease from Neisseria gonorrhoeae inhibits exocytosis in bovine chromaffin cells like tetanus toxin. J. Biol. , 270, 1770–1774. , Jahn, R.